Researchersunveildifferentresponsepatternsoftumor-infiltratingBcells_GuangmingOnlineBEIJING,May7(Xinhua)--Chineseresearchershaveunveiledtwodifferentresponsepatternsoftumor-infiltratingBcells,withimplicationsfortheimmunotherapytreatmentofcancer,accordingtoaresearcharticlepublishedrecentlyinthejournalScience.Bcellshavelongbeenconsideredanimportantcomponentoftumor-infiltratinglymphocytecells,althoughwhethertheyplayapositiveornegativeroleinanti-tumorimmunityremainshighlycontroversial.Inthisstudy,usingcomprehensivesingle-cellmultiomicanalysesofBcellsacross20cancertypes,theresearchersfromtheShanghaiInstituteofImmunityandInfection(SIII)oftheChineseAcademyofSciences,FudanUniversityandZhejiangUniversityclassifiedtheresponsesofdifferenttumor-infiltratingBcellsinrelationtodifferentcancertypes.TheyfoundthatdifferentBcellresponseswereassociatedwithdifferenttumorimmunitiesandprognosisoutcomes.Inaddition,throughextensiveanalyses,theresearchersdeterminedthemolecularfeaturesandthedifferentiationpathwaysoftheatypicalmemory(AtM)Bcells.ZhangXiaoming,professorwiththeSIII,saidthattheresearchersdidnotexpecttoidentifyanegativeroleforAtMBcellswithintumors,andthisknowledgecouldopenupnewavenuesforcancerimmunotherapybytargeteddampeningordepletionofAtMBcells.Thestudydeepenstheunderstandingofthedifferentfunctionsoftumor-infiltratingBcells.Itmayoffernewtreatmentoptionsforcancerpatientswhodonotrespondwelltoexistingimmunotherapies,theresearcharticlenoted.Withmechanisticinsightsandclinicalvalidation,B-cell-targetedtherapiesmaycomplementothertypesofimmunotherapyinthenearfuture.Editor:DisclaimerTheviewsandopinionsexpressedinthisarticlearethoseoftheauthor's,GMW.cnmakesnorepresentationsastoaccuracy,suitability,orvalidityofanyinformationonthissiteandwillnotbeliableforanyerrors,omissions,ordelaysinthisinformation.